// LPR Platform — shared mock data (Mariana's case is the canonical example) const LPR_PROTOCOL = { id: 'LPR-LR-1', name: 'LPR — Lifestyle Precision Reset', version: 'v1.4.2', status: 'Publicado', publishedAt: '2026-03-12', modules: ['LPR-DM2', 'LPR-Reganho', 'LPR-Adesão'], }; // 8 domínios LPR const LPR_DOMAINS = [ { id: 'metabolic', label: 'Metabólico', short: 'Metab', icon: 'Activity' }, { id: 'gut', label: 'Intestinal', short: 'Intest', icon: 'Apple' }, { id: 'mito', label: 'Mitocondrial', short: 'Mito', icon: 'Zap' }, { id: 'inflam', label: 'Inflamatório', short: 'Inflam', icon: 'Flame' }, { id: 'hormone', label: 'Neuroendócrino', short: 'Hormon', icon: 'Brain' }, { id: 'circadian', label: 'Circadiano/Sono', short: 'Circad', icon: 'Moon2' }, { id: 'body', label: 'Composição/Movim.', short: 'Corpo', icon: 'Dumbbell' }, { id: 'behavior', label: 'Comportamental', short: 'Comport',icon: 'Target' }, ]; // Mariana — paciente principal const MARIANA = { id: 'p-0421', name: 'Mariana Corrêa', age: 44, sex: 'F', mrn: 'MRN 04219', protocol: 'LPR — Lifestyle Precision Reset', protocolShort: 'LPR-LR-1 v1.4.2', cycle: 'Ciclo 2 · Dia 18 / 60', phase: 'Fase 1 — Reset Circadiano', startedAt: '2026-04-15', lastCheckin: 'há 12h', lastCheckinFull: '02/05/2026 · 07:42', doctor: 'Dr. Helena Marques', clinic: 'Longevium Clínica Médica', scoreGlobal: 58, // 0-100 scoreGlobalDelta: +4, // semana atual vs anterior scoreTrend: [42, 44, 41, 46, 49, 52, 55, 54, 56, 58], // últimas 10 semanas semaphore: 'yellow', // Por domínio: domains: { metabolic: { score: 58, semaphore: 'yellow', delta: +3, drivers: ['Variabilidade glicêmica (CGM)', 'HOMA-IR alterado', 'Insulina jejum 14 µUI/mL'], lastTrend: [50, 49, 52, 54, 56, 58], }, gut: { score: 54, semaphore: 'yellow', delta: +2, drivers: ['Distensão pós-prandial recorrente', 'Constipação 2-3x/semana', 'GI Symptom Score 11/30'], lastTrend: [48, 49, 50, 52, 53, 54], }, mito: { score: 52, semaphore: 'yellow', delta: +1, drivers: ['VO₂ estimado baixo', 'HRV reduzido (rMSSD 28ms)', 'Fadiga subjetiva 6/10'], lastTrend: [50, 51, 50, 51, 52, 52], }, inflam: { score: 60, semaphore: 'yellow', delta: 0, drivers: ['hsCRP 2.8 mg/L', 'Ferritina limítrofe (24 ng/mL)'], lastTrend: [58, 59, 58, 60, 60, 60], }, hormone: { score: 56, semaphore: 'yellow', delta: -1, drivers: ['Cortisol AM 22 µg/dL (alto)', 'Sintomas de perimenopausa', 'TSH 3.4 mUI/L'], lastTrend: [60, 58, 57, 56, 56, 56], }, circadian: { score: 38, semaphore: 'red', delta: +6, drivers: ['Início do sono ~01:30', 'Jet lag social 2h08', 'Acorda cansada 5/7 dias'], lastTrend: [22, 24, 28, 32, 36, 38], }, body: { score: 55, semaphore: 'yellow', delta: +2, drivers: ['Gordura visceral 9 (alta)', 'Massa magra perdendo (-0.4kg/mês)', 'Passos médios 4.2k'], lastTrend: [50, 51, 52, 53, 54, 55], }, behavior: { score: 41, semaphore: 'red', delta: +8, drivers: ['Adesão 58% (semana)', 'Alimentação emocional 3 episódios', 'Rotina inconsistente'], lastTrend: [25, 28, 30, 34, 38, 41], }, }, // Meta-classificação LPR classification: { leader: 'circadian', amplifier: 'behavior', saboteur: 'behavior', pattern: 'Desregulação circadiana como driver metabólico', }, riskModules: [ { id: 'LPR-DM2', label: 'LPR–DM2', level: 'moderate' }, { id: 'LPR-Reganho', label: 'LPR–Reganho de peso', level: 'high' }, { id: 'LPR-Adesão', label: 'LPR–Adesão', level: 'critical' }, ], // Próxima ação sugerida pelo sistema nextAction: { title: 'Continuar Fase 1 — Reset Circadiano', rationale: 'Padrão emergente: sono → glicemia → adesão. Estabilizar circadiano antes de qualquer intervenção metabólica.', blocks: [ { name: 'GLP-1 (semaglutida 0.25mg)', decision: 'Block', reason: 'Adesão crítica + comportamento instável' }, ], activates: [ 'Rotina de sono estruturada (janela 23:00–06:30)', 'Exposição solar 10 min na primeira hora', 'Janela alimentar 11:00–20:00', ], }, }; // Outros pacientes para a lista (nomes brasileiros plausíveis) const PATIENTS = [ MARIANA, { id: 'p-0387', name: 'Rafael Toledo', age: 52, sex: 'M', mrn: 'MRN 03872', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 1 · Dia 42/60', scoreGlobal: 72, scoreGlobalDelta: +2, semaphore: 'yellow', lastCheckin: 'há 4h', lastCheckinFull: '03/05/2026 · 06:10', redDomains: ['behavior'], yellowDomains: ['metabolic', 'body', 'mito'], greenDomains: ['gut','inflam','hormone','circadian'], alerts: 1, examsStatus: 'pending', adherence: 76, safety: 'allow', scoreTrend: [60, 64, 67, 70, 71, 72], }, { id: 'p-0512', name: 'Beatriz Lima', age: 38, sex: 'F', mrn: 'MRN 05123', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 3 · Dia 9/60', scoreGlobal: 81, scoreGlobalDelta: +3, semaphore: 'green', lastCheckin: 'há 6h', lastCheckinFull: '03/05/2026 · 05:40', redDomains: [], yellowDomains: ['hormone'], greenDomains: ['metabolic','gut','mito','inflam','circadian','body','behavior'], alerts: 0, examsStatus: 'validated', adherence: 92, safety: 'allow', scoreTrend: [72, 74, 76, 78, 80, 81], }, { id: 'p-0299', name: 'Eduardo Pacheco', age: 61, sex: 'M', mrn: 'MRN 02991', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 1 · Dia 22/60', scoreGlobal: 44, scoreGlobalDelta: -2, semaphore: 'red', lastCheckin: 'há 2d', lastCheckinFull: '01/05/2026 · 21:18', redDomains: ['metabolic','inflam'], yellowDomains: ['gut','mito','hormone','circadian','body','behavior'], greenDomains: [], alerts: 4, examsStatus: 'lowConfidence', adherence: 41, safety: 'block', scoreTrend: [50, 49, 48, 47, 45, 44], }, { id: 'p-0445', name: 'Luana Ferreira', age: 29, sex: 'F', mrn: 'MRN 04451', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 1 · Dia 5/60', scoreGlobal: 62, scoreGlobalDelta: +1, semaphore: 'yellow', lastCheckin: 'há 18h', lastCheckinFull: '02/05/2026 · 02:30', redDomains: [], yellowDomains: ['metabolic','behavior'], greenDomains: ['gut','mito','inflam','hormone','circadian','body'], alerts: 1, examsStatus: 'pending', adherence: 84, safety: 'caution', scoreTrend: [58, 59, 60, 60, 61, 62], }, { id: 'p-0156', name: 'Carlos Andrade', age: 57, sex: 'M', mrn: 'MRN 01561', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 2 · Dia 33/60', scoreGlobal: 67, scoreGlobalDelta: +5, semaphore: 'yellow', lastCheckin: 'há 8h', lastCheckinFull: '03/05/2026 · 03:50', redDomains: ['inflam'], yellowDomains: ['metabolic','body'], greenDomains: ['gut','mito','hormone','circadian','behavior'], alerts: 2, examsStatus: 'validated', adherence: 88, safety: 'modify', scoreTrend: [60, 62, 63, 64, 66, 67], }, { id: 'p-0703', name: 'Sofia Mendonça', age: 35, sex: 'F', mrn: 'MRN 07033', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 1 · Dia 12/60', scoreGlobal: 53, scoreGlobalDelta: +1, semaphore: 'yellow', lastCheckin: 'há 1d', lastCheckinFull: '02/05/2026 · 13:00', redDomains: ['behavior'], yellowDomains: ['metabolic','gut','hormone','circadian'], greenDomains: ['mito','inflam','body'], alerts: 2, examsStatus: 'pending', adherence: 62, safety: 'allow', scoreTrend: [49, 50, 51, 51, 52, 53], }, { id: 'p-0810', name: 'Pedro Vasconcelos', age: 48, sex: 'M', mrn: 'MRN 08109', protocol: 'LPR-LR-1 v1.4.2', protocolShort: 'LPR-LR-1', cycle: 'Ciclo 2 · Dia 51/60', scoreGlobal: 76, scoreGlobalDelta: +4, semaphore: 'green', lastCheckin: 'há 3h', lastCheckinFull: '03/05/2026 · 09:12', redDomains: [], yellowDomains: ['hormone','body'], greenDomains: ['metabolic','gut','mito','inflam','circadian','behavior'], alerts: 0, examsStatus: 'validated', adherence: 95, safety: 'allow', scoreTrend: [68, 70, 71, 73, 75, 76], }, ]; // Resumo MARIANA para a lista (sintetizado) PATIENTS[0].redDomains = ['circadian','behavior']; PATIENTS[0].yellowDomains = ['metabolic','gut','mito','inflam','hormone','body']; PATIENTS[0].greenDomains = []; PATIENTS[0].alerts = 3; PATIENTS[0].examsStatus = 'pending'; PATIENTS[0].adherence = 58; PATIENTS[0].safety = 'block'; // Exames laboratoriais (Mariana, último painel) const EXAMS_PANEL = [ { name: 'Glicemia jejum', value: 98, unit: 'mg/dL', refLab: '70–99', refProto: '70–95', status: 'borderline', domain: 'metabolic' }, { name: 'Insulina jejum', value: 14, unit: 'µUI/mL', refLab: '2.6–24.9', refProto: '<8', status: 'high', domain: 'metabolic' }, { name: 'HOMA-IR', value: 3.4, unit: '', refLab: '<2.7', refProto: '<1.8', status: 'high', domain: 'metabolic' }, { name: 'HbA1c', value: 5.6, unit: '%', refLab: '<5.7', refProto: '<5.4', status: 'borderline', domain: 'metabolic' }, { name: 'hsCRP', value: 2.8, unit: 'mg/L', refLab: '<3.0', refProto: '<1.0', status: 'high', domain: 'inflam' }, { name: 'Ferritina', value: 24, unit: 'ng/mL', refLab: '13–150', refProto: '50–150', status: 'low', domain: 'inflam' }, { name: '25-OH Vitamina D', value: 28, unit: 'ng/mL', refLab: '30–100', refProto: '40–60', status: 'low', domain: 'mito' }, { name: 'Vitamina B12', value: 412, unit: 'pg/mL', refLab: '200–900', refProto: '500–900',status: 'borderline', domain: 'mito' }, { name: 'TSH', value: 3.4, unit: 'mUI/L', refLab: '0.4–4.5', refProto: '<2.5', status: 'high', domain: 'hormone' }, { name: 'T4 livre', value: 1.1, unit: 'ng/dL', refLab: '0.9–1.7', refProto: '1.1–1.5',status: 'normal', domain: 'hormone' }, { name: 'Cortisol manhã', value: 22, unit: 'µg/dL', refLab: '6.7–22.6', refProto: '8–18', status: 'high', domain: 'hormone' }, { name: 'Triglicerídeos', value: 142, unit: 'mg/dL', refLab: '<150', refProto: '<100', status: 'borderline', domain: 'metabolic' }, { name: 'HDL', value: 48, unit: 'mg/dL', refLab: '>40', refProto: '>55', status: 'low', domain: 'metabolic' }, { name: 'LDL', value: 128, unit: 'mg/dL', refLab: '<130', refProto: '<100', status: 'borderline', domain: 'metabolic' }, { name: 'GGT', value: 36, unit: 'U/L', refLab: '<38', refProto: '<25', status: 'borderline', domain: 'metabolic' }, ]; // Lista de uploads de exames const EXAM_UPLOADS = [ { id: 'u1', file: 'Painel_metabolico_Apr2026.pdf', size: '342 KB', uploadedAt: '02/05/2026 · 11:08', status: 'validated', markers: 8, lab: 'Fleury', confidence: 0.98 }, { id: 'u2', file: 'Hormonal_completo_Apr2026.pdf', size: '298 KB', uploadedAt: '02/05/2026 · 11:08', status: 'validated', markers: 6, lab: 'Fleury', confidence: 0.96 }, { id: 'u3', file: 'CGM_export_28d.csv', size: '1.2 MB', uploadedAt: '01/05/2026 · 22:14', status: 'extracted', markers: 1, lab: 'Freestyle Libre', confidence: 0.99 }, { id: 'u4', file: 'Tireoide_painel.pdf', size: '210 KB', uploadedAt: '30/04/2026 · 09:42', status: 'lowConfidence', markers: 2, lab: 'Sabin', confidence: 0.62 }, { id: 'u5', file: 'Composicao_corporal_dexa.pdf', size: '1.8 MB', uploadedAt: '28/04/2026 · 14:30', status: 'pending', markers: 0, lab: 'Bioscan', confidence: null }, ]; // Questionários const QUESTIONNAIRES = [ { id: 'lpr-onb', name: 'LPR Onboarding', freq: 'Início', last: '15/04/2026', score: 42, max: 100, domains: ['metabolic','behavior','circadian','hormone'] }, { id: 'lpr-daily', name: 'LPR Daily', freq: 'Diário', last: 'hoje', score: 6.2, max: 10, domains: ['behavior','circadian','mito'] }, { id: 'gi-sym', name: 'GI Symptom Score', freq: 'Semanal', last: '28/04/2026', score: 11, max: 30, domains: ['gut'] }, { id: 'psqi', name: 'PSQI (Pittsburgh)', freq: '4 semanas', last: '20/04/2026', score: 11, max: 21, domains: ['circadian'] }, { id: 'phq-9', name: 'PHQ-9', freq: '4 semanas', last: '20/04/2026', score: 8, max: 27, domains: ['behavior','hormone'] }, { id: 'gad-7', name: 'GAD-7', freq: '4 semanas', last: '20/04/2026', score: 7, max: 21, domains: ['behavior','hormone'] }, { id: 'who5', name: 'WHO-5 Bem-estar', freq: '2 semanas', last: '22/04/2026', score: 56, max: 100, domains: ['behavior'] }, { id: 'meno-q', name: 'Menopause Rating Scale', freq: '4 semanas', last: '20/04/2026', score: 18, max: 44, domains: ['hormone'] }, { id: 'pss-10', name: 'PSS-10 (Estresse)', freq: '2 semanas', last: 'pendente', score: null, max: 40, domains: ['hormone','behavior'] }, { id: 'food-freq', name: 'Frequência alimentar', freq: 'Mensal', last: '15/04/2026', score: null, max: null, domains: ['metabolic','gut'] }, ]; // Alertas const ALERTS = [ { id: 'a1', sev: 'high', for: 'doctor', domain: 'behavior', patient: 'Mariana Corrêa', text: 'Adesão semanal 58% — abaixo do limiar do protocolo (70%)', when: 'há 12h', kind: 'trend' }, { id: 'a2', sev: 'high', for: 'doctor', domain: 'circadian', patient: 'Mariana Corrêa', text: 'Padrão emergente: piora progressiva do sono + variabilidade glicêmica', when: 'há 1d', kind: 'pattern' }, { id: 'a3', sev: 'high', for: 'doctor', domain: null, patient: 'Mariana Corrêa', text: 'Safety Engine: GLP-1 BLOQUEADO — adesão crítica + comportamento instável', when: 'há 2d', kind: 'safety' }, { id: 'a4', sev: 'medium', for: 'doctor', domain: 'hormone', patient: 'Mariana Corrêa', text: 'Cortisol AM 22 µg/dL acima da referência do protocolo (8–18)', when: 'há 3d', kind: 'lab' }, { id: 'a5', sev: 'medium', for: 'doctor', domain: null, patient: 'Eduardo Pacheco', text: 'Exame Tireoide_painel.pdf com baixa confiança de extração (62%)', when: 'há 5h', kind: 'data' }, { id: 'a6', sev: 'high', for: 'doctor', domain: 'metabolic', patient: 'Eduardo Pacheco', text: 'Glicemia jejum 142 mg/dL — fora do esperado para o ciclo', when: 'há 8h', kind: 'lab' }, { id: 'a7', sev: 'low', for: 'doctor', domain: null, patient: 'Sofia Mendonça', text: 'Dados faltantes: PSS-10 não respondido há 14 dias', when: 'há 1d', kind: 'data' }, { id: 'a8', sev: 'medium', for: 'patient', domain: 'circadian', patient: 'Mariana Corrêa', text: 'Você dormiu menos de 6h em 4 dos últimos 7 dias', when: 'hoje', kind: 'trend' }, { id: 'a9', sev: 'low', for: 'patient', domain: 'behavior', patient: 'Mariana Corrêa', text: 'Lembrete: questionário PSS-10 disponível', when: 'hoje', kind: 'data' }, ]; // Decisões do Safety Engine (histórico para Mariana) const SAFETY_HISTORY = [ { id: 'sd1', date: '01/05/2026', intervention: 'GLP-1 (semaglutida 0.25mg)', decision: 'Block', by: 'Sistema', reason: 'Adesão crítica + comportamento instável', rules: ['R-014', 'R-022'] }, { id: 'sd2', date: '24/04/2026', intervention: 'Treino de força 3x/sem', decision: 'Modify', by: 'Sistema', reason: 'Massa magra perdendo — reduzir volume, prioridade técnica', rules: ['R-031'] }, { id: 'sd3', date: '18/04/2026', intervention: 'Jejum intermitente 16:8', decision: 'Postpone', by: 'Sistema', reason: 'Cortisol AM elevado + sono instável', rules: ['R-008', 'R-019'] }, { id: 'sd4', date: '15/04/2026', intervention: 'Reset Circadiano', decision: 'Allow', by: 'Sistema', reason: 'Driver primário identificado', rules: ['R-001'] }, ]; // Regras do Safety Engine (mocks) const SAFETY_RULES = [ { id: 'R-001', name: 'Permitir reset circadiano sempre', sev: 'low', enabled: true, cond: 'IF protocolo == LPR-LR-1', then: 'Allow Reset Circadiano', affectedDomains: ['circadian'], requireReview: false, allowOverride: true }, { id: 'R-008', name: 'Postergar jejum se cortisol alto', sev: 'medium', enabled: true, cond: 'IF cortisol_am > 18 AND psqi >= 8', then: 'Postpone Jejum Intermitente', affectedDomains: ['hormone','circadian'], requireReview: false, allowOverride: true }, { id: 'R-014', name: 'Bloquear GLP-1 se adesão crítica', sev: 'high', enabled: true, cond: 'IF adesao_semanal < 60% AND comportamental == red', then: 'Block GLP-1', affectedDomains: ['behavior','metabolic'], requireReview: true, allowOverride: true }, { id: 'R-019', name: 'Cautela em restrição calórica com sono ruim', sev: 'medium', enabled: true, cond: 'IF psqi >= 10 AND deficit_calorico > 500', then: 'Caution Dieta Restritiva', affectedDomains: ['circadian','metabolic','behavior'], requireReview: false, allowOverride: true }, { id: 'R-022', name: 'Revisão médica obrigatória — comportamento crítico', sev: 'high', enabled: true, cond: 'IF risco_LPR-Adesao == critical', then: 'Require Medical Review', affectedDomains: ['behavior'], requireReview: true, allowOverride: false }, { id: 'R-031', name: 'Modificar treino se massa magra cai', sev: 'medium', enabled: true, cond: 'IF delta_massa_magra < -0.3 kg/mes', then: 'Modify Treino Intenso', affectedDomains: ['body','mito'], requireReview: false, allowOverride: true }, { id: 'R-045', name: 'Bloquear restrição se ferritina baixa', sev: 'high', enabled: true, cond: 'IF ferritina < 30 AND dieta_restritiva == true', then: 'Block Dieta Restritiva', affectedDomains: ['inflam','metabolic'], requireReview: true, allowOverride: true }, { id: 'R-051', name: 'Cautela suplementação ferro com PCR alta', sev: 'low', enabled: false, cond: 'IF hsCRP > 3.0 AND suplemento == ferro', then: 'Caution Suplementação Ferro', affectedDomains: ['inflam'], requireReview: false, allowOverride: true }, ]; // LPR Daily — perguntas (mobile) const DAILY_QUESTIONS = [ { id: 'sleep', type: 'scale', label: 'Dormi bem?', min: 0, max: 10, value: 4, hint: '0 = muito mal · 10 = perfeito' }, { id: 'energy', type: 'scale', label: 'Energia hoje?', min: 0, max: 10, value: 5 }, { id: 'mood', type: 'scale', label: 'Humor?', min: 0, max: 10, value: 6 }, { id: 'stress', type: 'scale', label: 'Estresse hoje?', min: 0, max: 10, value: 7, inverse: true }, { id: 'evac', type: 'yesno', label: 'Evacuação hoje?', value: true }, { id: 'bristol', type: 'bristol', label: 'Escala de Bristol', value: 4 }, { id: 'bloat', type: 'scale', label: 'Distensão abdominal?', min: 0, max: 10, value: 3, inverse: true }, { id: 'plan', type: 'percent', label: 'Segui o plano?', value: 70 }, { id: 'pain', type: 'scale', label: 'Dor hoje?', min: 0, max: 10, value: 1, inverse: true }, { id: 'exercise', type: 'yesno', label: 'Fiz exercício?', value: true }, { id: 'meds', type: 'yesno', label: 'Tomei medicamentos/suplementos?', value: true }, { id: 'note', type: 'text', label: 'Observação livre', value: '' }, ]; Object.assign(window, { LPR_PROTOCOL, LPR_DOMAINS, MARIANA, PATIENTS, EXAMS_PANEL, EXAM_UPLOADS, QUESTIONNAIRES, ALERTS, SAFETY_HISTORY, SAFETY_RULES, DAILY_QUESTIONS, });